DOCK1 Polyclonal Antibody, Cy5 Conjugated

• Background:

  Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.Tissue specificity: Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon.

• Synonyms:

  180 kDa protein downstream of CRK; Ced5; Dedicator of Cytokinesis 1; Dedicator of cytokinesis protein 1; DOCK 1; DOCK-1; DOCK 180; DOCK1; DOCK1_HUMAN; DOCK180.

• Gene ID:

  1793

• Cellular Locus:

  Cytoplasm, Cell membrane

• Host:

  Rabbit

• Cross Reactivity:

  Mouse

• Immunogen:

  465-550/1865

• Target:

  DOCK1

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Conjugation:

  Cy5

• Source:

  KLH conjugated synthetic peptide derived from human DOCK1

• Applications:

  IF (IHC-P), IF (IHC-F), IF (ICC)

• Purification:

  Purified by Protein A.

• Excitation Emission:

  625,650nm/670nm

• Concentration:

  1µg/µl

• Dilution:

  IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

• Buffer:

  Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification:

  Unmodified

• Storage Conditions:

  Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

• Gene ID URL:

  1793

• Predicted Cross Reactivity:

  Human, Rat, Dog, Cow, Sheep, Horse, Chicken