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ShcA Antibody

CAT: 0498-bs-70659RSize: 100 µLDry Ice: NoHazardous: No
CAT#:0498-bs-70659RSize:100 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The adapter protein Shc was initially identified as an SH2 containing proto-oncogene involved in growth factor signaling. Since then, a number of studies in multiple systems have implicated a role for Shc in many different types of signal transduction including growth factor, antigen, cytokine, G-protein, hormone, and integrin receptor signaling. In addition to the ubiquitous ShcA, there are two other shc gene products, ShcB and ShcC, which are predominantly expressed in neuronal cells. ShcA knockout mice are embryonic lethal and have clearly suggested an important role for ShcA in vivo. An important role for Shc in the activation of MAPK pathway has been established. Thus, Shc adapter proteins are critical components of signal transduction pathways involved in many different cellular processes.
Synonyms
SH2 C1, SHC
Swiss Prot
P29353
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat, Rabbit
Target
ShcA
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
A recombinant protein that included amino acid residues within the C-terminal region of human ShcA. This sequence has high homology with similar regions in rat and mouse ShcA.
Applications
WB
Purification
Antigen Affinity purification
Dilution
WB (1:300-5000)
Buffer
PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Modification
Unmodified
Storage Conditions
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Specificity
The antibody detects 46/52/66 kDa* bands corresponding to the molecular weight of ShcA variants on SDS-PAGE immunoblots of A431 cells. It also detects ShcA in human Jurkat, HeLa, and SKN-SH cells, as well as rat brain tissue and rabbit spleen fibroblasts.

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