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SARM1 Antibody

CAT: 0498-bs-70254RSize: 100 µLDry Ice: NoHazardous: No
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CAT#:0498-bs-70254RSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NAD (+) hydrolase sterile alpha and TIR motif-containing protein 1 (SARM1), is the fifth member of the Toll/Il-1 Receptor (TIR) domain protein family. The highly conserved 724 amino acid protein is predominantly expressed in the brain, kidney and liver (Mink, M., et al 2001) . Furthermore, SARM1 is enriched in the cytoplasm, mitchondria, and the axons, dendrites, and synapses of neurons (Panneerselvam, P., et al, 2012) . SARM1 plays a key role in axonal degeneration by catalyzing the cleavage of NAD+ into ADPR, cADPR, and nicotinamide in response to injury triggering Wallerian degeneration (Gerdts, J. et al 2015) . SARM1 has also been shown to activate neuronal cell death in response to stress (Peng, J. et al. 2010) .
Synonyms
FLJ36296 antibody, KIAA0524 antibody, MyD88-5 antibody, SAM and ARM-containing protein antibody, SAM domain-containing protein 2 antibody, SAMD2 antibody, SARM 1 antibody, SARM1 antibody, SARM1_HUMAN antibody, Sterile alpha and Armadillo repeat protein antibody, sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila antibody, sterile alpha and HEAT/Armadillo motifs-containing protein antibody, sterile alpha and TIR motif containing 1 antibody, Sterile alpha and TIR motif-containing protein 1 antibody, Sterile alpha and TIR motifs-containing protein 1 antibody, Sterile alpha motif domain-containing protein 2 antibody, Tir-1 homolog antibody
Gene ID
23098
Swiss Prot
Q6SZW1
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
SARM1
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
Full length recombinant human SARM1 protein
Applications
WB
Purification
Antigen Affinity purification from Pooled whole antiserum
Concentration
Lot Dependent
Dilution
WB (1:300-5000)
Buffer
10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Modification
Unmodified
Storage Conditions
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Specificity
Specific for endogenous levels of the ~79 kDa SARM1 protein.
Gene ID URL
23098

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