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PanK4 (Thr63) Antibody

CAT: 0498-bs-70214RSize: 100 µLDry Ice: NoHazardous: No
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CAT#:0498-bs-70214RSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Pantothenate kinase, PanK, is a vital regulatory enzyme for coenzyme A (CoA) biosynthesis, phosphorylating pantothenate (vitamin B5) to 4’-phosphopantothenate, then quickly transforming to CoA which is an essential component for fatty acid metabolism (Abiko, Y, 1967) . There are 4 members of the PanK family, located on chromosomes 10q23.31, 20p13, 5q35, and 1p36.32 (Zhou et al, 2001) . PanK1 is predominantly in heart, liver, and kidney. PanK2 is expressed ubiquitously, with higher levels in retinal and infant basal ganglia. PanK3 has high levels in liver, while PanK4 is expressed ubiquitously with its highest levels found in muscle (Zhou et al, 2001) . Additionally, PanK4 has been shown to regulate Pkm2 activity affecting glucose metabolism (Li et al, 2005) . There have been several phospho-serine, threonine, and tyrosine sites identified within PanK4, the role of each one has yet to be determined.
Synonyms
DKFZp547M242 antibody, FLJ10782 antibody, hPanK 4 antibody, hPanK4 antibody, PANK 4 antibody, Pantothenate kinase 4 antibody, Pantothenic acid kinase antibody
Gene ID
269614
Swiss Prot
Q80YV4
Modification Site
Thr63
Host
Rabbit
Cross Reactivity
Mouse
Target
PanK4 (Thr63)
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr63 of mouse PanK4, conjugated to keyhole limpet hemocyanin (KLH) .
Applications
WB
Purification
Antigen Affinity purification from Pooled whole antiserum
Concentration
Lot Dependent
Dilution
WB (1:300-5000)
Buffer
10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Modification
Phosphorylation
Storage Conditions
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Specificity
Specific for the ~86 kDa PanK4 phosphorylated at Ser63. Immunolabeling of PanK4 is nearly eliminated with λ-phosphatase treatment.
Gene ID URL
269614
Predicted Cross Reactivity
Rat, Hamster

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