GAP43 Antibody

• Background:

  GAP-43 is thought to have an important role in development and plasticity because it is expressed at high levels in neuronal growth cones during development and during axonal regeneration (Benowitz and Routtenberg, 1997) . There is also evidence from knockout animals that GAP-43 serves to amplify pathfinding signals from the growth cone (Strittmatter et al., 1995) . GAP-43 is thought to mediate at least some of these effects via interaction with actin. Importantly, phosphorylation at Ser-41 by protein kinase C modulates the interaction of GAP-43 with actin (He et al., 1997) and may also affect neurotransmitter release during forms of plasticity like LTP (Hulo et al., 2002) .

• Synonyms:

  Axonal membrane protein GAP 43 antibody, Axonal membrane protein GAP-43 antibody, B 50 antibody, Calmodulin binding protein P 57 antibody, F1 antibody, GAP 43 antibody, GAP-43 antibody, GAP43 antibody, Growth Associated Protein 43 antibody, Growth-associated protein 43 antibody, Nerve Growth Related Peptide antibody, Nerve growth related peptide GAP43 antibody, NEUM_HUMAN antibody, Neural phosphoprotein B 50 antibody, Neural phosphoprotein B-50 antibody, Neuromodulin antibody, Neuron growth associated protein 43 antibody, PP46 antibody, Protein F1 antibody, QtrA-11580 antibody, QtrA-13071 antibody

• Gene ID:

  29423

• Swiss Prot:

  P07936

• Host:

  Chicken

• Cross Reactivity:

  Human, Mouse, Rat, Bovine, Horse

• Target:

  GAP43

• Clonality:

  Polyclonal

• Isotype:

  IgY

• Conjugation:

  Unconjugated

• Source:

  Synthetic peptide corresponding to amino acid residues from the C-terminal region of rat GAP43, conjugated to keyhole limpet hemocyanin (KLH) .

• Applications:

  WB, IHC

• Purification:

  Total IgY fraction

• Concentration:

  Lot Dependent

• Dilution:

  WB (1:300-5000), IHC ()

• Buffer:

  PBS + 10 mM NaN3.

• Modification:

  Unmodified

• Storage Conditions:

  Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

• Specificity:

  Specific for endogenous levels of the ~43 kDa GAP-43 protein.

• Gene ID URL:

  29423