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CaSR Antibody

CAT: 0498-bs-70032RSize: 100 µLDry Ice: NoHazardous: No
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CAT#:0498-bs-70032RSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Calcium sensing receptor, CaSR, is a unique G protein-coupled receptor activated by extracellular Ca2+, Mg2+, Sr2+, Mn2+, Ba2+, Ni2+, Al2+, Gd3+, amino acids, polyamines, pH and ionic strength (Quinn, S.J. et al., 1998) . CaSR is a cell surface dimer located in the caveolin-rich plasma membrane domains (Kifor, O., et al., 1998) . CaSR tightly regulates extracellular calcium levels to avoid hyper/hypo-calcemia through complex interactions with PTH, calcitonin, and vitamin D by balancing their effects on the parathyroid glands, bone, kidney, and intestine (Díaz-Soto, G. et al., 2016) . Additionally, CaSR has been identified in the nervous system and recent studies suggest CaSR as a direct target of reducing Aβ42 secretion that may contribute to Alzheimer’s Disease (Armato, U., et al., 2013) . Recent studies have shown CaSR negatively impacts the formation and progression of neuroblastomas by calcium exposure leading NB cells overexpressing CaSR to undergo apoptosis by means of activating ERK1/2 (Casalà, C., et al., 2013) .
Synonyms
Ca sensing receptor antibody, Ca2+ sensing receptor 1 antibody, Ca2+ sensing receptor antibody, Calcium sensing receptor antibody, CAR antibody, CaSR antibody, CASR_HUMAN antibody, Extracellular calcium sensing receptor antibody, Extracellular calcium sensing receptor [Precursor] antibody, Extracellular calcium-sensing receptor antibody, FHH antibody, FIH antibody, GPRC2A antibody, HHC antibody, HHC1 antibody, Hypocalciuric hypercalcemia 1 antibody, Hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism antibody, MGC138441 antibody, NSHPT antibody, Parathyroid Ca (2+) sensing receptor 1 antibody, Parathyroid Cell calcium sensing receptor antibody, Parathyroid Cell calcium-sensing receptor antibody, PCAR 1 antibody, PCaR1 antibody
Gene ID
24247
Swiss Prot
P48442
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
CaSR
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
Synthetic peptide from the N-terminus region of rat calcium sensing receptor, conjugated to keyhole limpet hemocyanin (KLH) .
Applications
WB
Purification
Antigen Affinity purification from Pooled whole antiserum
Concentration
Lot Dependent
Dilution
WB (1:300-5000)
Buffer
10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Modification
Unmodified
Storage Conditions
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Specificity
Specific for endogenous levels of the ~130-260 kDa CaSR protein.
Gene ID URL
24247

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