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FAIM2 Polyclonal Antibody

CAT: 0498-bs-6831RSize: 100 µLDry Ice: NoHazardous: No
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CAT#:0498-bs-6831RSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Programmed cell death regulates a number of biological processes such as normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. FAIM2 is a recently identified protein that can inhibit the apoptotic signal transduced by the Fas receptor but not from the related tumor necrosis factor-alpha death signal. In this respect, FAIM2 is functionally similar to the anti-apoptotic proteins FAIM, FLIP and Bcl-xL. FAIM2, a seven membrane spanning protein, can bind the Fas receptor but does not regulate Fas expression or inhibit binding of FADD to Fas. FAIM2 is widely distributed, but highly expressed in the hippocampus and other neural tissues. FAIM2 was also identified as the neural membrane protein 35 (NMP35) and its expression is known to be regulated by the Phosphatidylinositol 3-kinase-Akt/PKB pathway.
Synonyms
FAIM 2; Fas apoptotic inhibitory molecule 2; LFG; Leguard; Neural membrane protein 35; NGP 35; NGP35; NMP 35; NMP35; Protein leguard; TMBIM 2; TMBIM2; Transmembrane BAX inhibitor mot containing 2; Transmembrane BAX inhibitor mot containing protein 2; LFG2_HUMAN.
Gene ID
23017
Cellular Locus
Cell membrane
Host
Rabbit
Immunogen
211-316/316
Target
FAIM2
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human FAIM2
Applications
ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
23017
Predicted Cross Reactivity
Human, Mouse, Rat, Dog, Sheep, Pig, Horse, Chicken, Rabbit, Monkey

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