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Mesopram

CAT: 0804-HY-108622-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108622-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mesopram (Daxalipram) is an orally active phosphodiesterase (PDE) 4 inhibitor. Mesopram inhibits the synthesis of proinflammatory cytokines TNF-α and IFN-γ. Mesopram demonstrates efficacy in ameliorating Dextran sulfate sodium (DSS) -induced murine colitis. Mesopram can be used for the study of chronic inflammatory diseases[1][2].
CAS Number
189940-24-7
Product Name Alternative
Daxalipram
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
IFNAR; Interleukin Related; Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mesopram.html
Purity
98.80
Solubility
10 mM in DMSO
Smiles
O=C1O[C@](C)(C2=CC=C(OC)C(OCCC)=C2)CN1
Molecular Formula
C14H19NO4
Molecular Weight
265.30
Precautions
H302, H315, H319, H335
References & Citations
[1]Blednov YA, et al. Inhibition of phosphodiesterase 4 reduces ethanol intake and preference in C57BL/6J mice. Front Neurosci. 2014 May 27;8:129.|[2]Loher F, et al. The specific type-4 phosphodiesterase inhibitor mesopram alleviates experimental colitis in mice. J Pharmacol Exp Ther. 2003 May;305 (2) :549-56.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
PDE4

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