CD2BP3 Polyclonal Antibody

CAT: 0498-bs-6239RSize: 100 µLDry Ice: NoHazardous: No
CAT#:0498-bs-6239RSize:100 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SH3KBP1 belongs to the CIN85/CMS family of adaptor molecules, characterized by containing three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The different members of the family orchestrate a network involved in dowregulation and degradation of recpetor tyrosine kinases. SH3KBP1 is involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. In the case of EGF receptor turnover, its activation involves recruitment of SH3KBP1- endophilin complexes to mediate internalization. Once internalized, RTKs are delivered into the endosomal compartment where receptors get sorted for either recycling back to the cell surface or are targeted to lysosomes for degradation. Alternate splicing results in multiple transcript variants.
Synonyms
Cbl interacting protein; Cbl interacting protein of 85 kDa; CD2 binding protein 3; CD2BP3; CIN 85; CIN85; GIG 10; GIG10; HSB 1; Human Src family kinase binding protein 1; MIG 18; MIG18; Migration inducing gene 18 protein; SH3 domain kinase binding protein 1; SH3BP 1; Src family kinase binding protein 1; src related kinase binding protein 1; SH3K1_HUMAN.
Gene ID
30011
Cellular Locus
Cytoplasm, Cell membrane
Host
Rabbit
Immunogen
591-665/665
Target
CD2BP3
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human SH3KBP1
Applications
WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
30011
Predicted Cross Reactivity
Human, Mouse, Rat, Cow, Sheep, Chicken, Rabbit

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