Phospho-LLGL1 + LLGL2 (Ser650+Ser654) Polyclonal Antibody, Biotin Conjugated

• Background:

  LLGL1 is a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene for LLGL1 is located within the Smith-Magenis syndrome region on chromosome 17. LLGL2 is a protein similar to lethal giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC) . In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells.

• Synonyms:

  LLGL1 + LLGL2 phospho S650 + S654; LLGL1 + LLGL2 phospho Ser650 + Ser654; p-LLGL1 + p-LLGL2 S650 + S654; p-LLGL1/LLGL2 Ser650 + Ser654; p-LLGL1/LLGL2 S650 + S654; p-LLGL1/LLGL2 Ser650/654; DLG4; HGL; HUGL; HUGL1; lethal giant larvae homolog 1; lethal giant larvae homolog 2; Lethal2 giant larvae protein homolog 1; Lethal2 giant larvae protein homolog 2; LGL2; LLGL; L2GL1_HUMAN; L2GL2_HUMAN.

• Gene ID:

  3996

• Modification Site:

  Ser650+Ser654

• Cellular Locus:

  Cytoplasm, Cell membrane

• Host:

  Rabbit

• Cross Reactivity:

  Rat

• Target:

  Phospho-LLGL1 + LLGL2 (Ser650+Ser654)

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Conjugation:

  Biotin

• Source:

  KLH conjugated synthetic phosphopeptide derived from mouse LLGL1 around the phosphorylation site of Ser650+Ser654

• Applications:

  WB, ELISA, IHC-P, IHC-F

• Purification:

  Purified by Protein A.

• Concentration:

  1µg/µl

• Dilution:

  WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500)

• Buffer:

  Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification:

  Phosphorylation

• Storage Conditions:

  Store at -20°C for 12 months.

• Gene ID URL:

  3996

• Predicted Cross Reactivity:

  Human, Mouse, Dog, Cow, Pig, Horse, Chicken, Guinea Pig