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MSH6 Polyclonal Antibody

CAT: 0498-bs-55135RSize: 100 µLDry Ice: NoHazardous: No
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CAT#:0498-bs-55135RSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.
Synonyms
MSH6; GTBP; GTMBP; HNPCC5; HSAP; p160
Gene ID
2956
Swiss Prot
P52701
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Human, Mouse, Monkey
Target
MSH6
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human MSH6 (NP_000170.1) .
Applications
WB, IHC, IF
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), IHC (), IF ()
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
2956