DNMT1 Polyclonal Antibody

CAT: 0498-bs-55056RSize: 100 µLDry Ice: NoHazardous: No
CAT#:0498-bs-55056RSize:100 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.
Synonyms
ADCADN; AIM; CXXC9; DNMT; HSN1E; MCMT; m.HsaI; DNMT1
Gene ID
1786
Swiss Prot
P26358
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Human
Immunogen
1-270/1616
Target
DNMT1
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human DNMT1 (NP_001370.1) .
Applications
WB, IF (ICC), IP, IF
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (ICC) (1:50-200), IP (1-2ug), IF ()
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Specificity
KO-Validated
Gene ID URL
1786

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