JMJD2a Polyclonal Antibody

CAT: 0498-bs-53136RSize: 50 µgDry Ice: NoHazardous: No
CAT#:0498-bs-53136RSize:50 µg
Selected
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.
Synonyms
JHDM3A, KDM4A, JMJD2, Lysine-specific demethylase 4A
Gene ID
9682
Swiss Prot
O75164
Host
Rabbit
Cross Reactivity
Human
Target
JMJD2a
Clonality
Polyclonal
Conjugation
Unconjugated
Source
Polyclonal antibody raised in rabbit against human JMJD2a (Jumonji domain containing 2a), using a KLH-conjugated synthetic peptide containing a sequence from the central part of the protein
Applications
WB, ELISA, IF
Purification
Affinity purified polyclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300.
Concentration
0.6µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IF ()
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
9682

Popular Products