MeCP2 Polyclonal Antibody

• Background:

  Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) -containing DNA, with a preference for 5-methylcytosine (5mC) .

• Synonyms:

  Methyl-CpG-binding protein 2, MECP2, MeCp-2 protein

• Gene ID:

  4204

• Swiss Prot:

  P51608

• Host:

  Rabbit

• Cross Reactivity:

  Human

• Target:

  MeCP2

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Source:

  Polyclonal antibody raised in rabbit against MeCP2 (Methyl-CpG-binding domain protein 2), using a KLH-conjugated synthetic peptide containing a sequence from the C-terminal part of the protein

• Applications:

  WB, ELISA, dot-blot

• Purification:

  Affinity purified polyclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300.

• Concentration:

  1.2µg/µl

• Dilution:

  WB (1:300-5000), ELISA (1:500-1000), dot-blot ()

• Buffer:

  0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification:

  Unmodified

• Storage Conditions:

  Store at -20°C for 12 months.

• Gene ID URL:

  4204