Mbd2 Polyclonal Antibody

• Background :

  Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.

• Synonyms :

  Methyl-CpG-binding domain protein 2, MBD2, DMTase, Methyl-CpG-binding protein MBD2

• Gene ID :

  8932

• Swiss Prot :

  Q9UBB5

• Host :

  Rabbit

• Cross Reactivity :

  Mouse

• Target :

  MBD2

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Source :

  Polyclonal antibody raised in rabbit against mouse MBD2, using a KLH-conjugated synthetic peptide containing an amino acid sequence from the central part of the protein

• Applications :

  WB, ELISA

• Purification :

  Whole antiserum from rabbit containing 0.05% azide

• Concentration :

  Not Determined

• Dilution :

  WB (1:300-5000), ELISA (1:500-1000)

• Buffer :

  0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification :

  Unmodified

• Storage Conditions :

  Store at -20°C for 12 months.

• Gene ID URL :

  8932