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Volanesorsen

CAT: 0804-HY-145727-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-145727-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Volanesorsen (ISIS 304801) is an antisense oligonucleotide inhibitor of apolipoprotein CIII (apo-CIII) mRNA that reduces triglyceride levels and improves insulin resistance. Volanesorsen is being studied in the treatment of hypertriglyceridemia, familial chylosiderosis syndrome, and type 2 diabetes[1][2][3][4][5].
CAS Number
915430-78-3
Product Name Alternative
ISIS 304801
UNSPSC
12352208
Target
Apolipoprotein
Type
Oligonucleotides
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/volanesorsen.html
Purity
97.97
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
[Volanesorsen]
Molecular Formula
C230H320N63O125P19S19
Molecular Weight
7165.00
References & Citations
[1]Graham MJ, Lee RG, Bell TA 3rd, et al. Antisense oligonucleotide inhibition of apolipoprotein C-III reduces plasma triglycerides in rodents, nonhuman primates, and humans. Circ Res. 2013;112 (11) :1479-1490. |[2]Gaudet D, Brisson D, Tremblay K, et al. Targeting APOC3 in the familial chylomicronemia syndrome. N Engl J Med. 2014;371 (23) :2200-2206. |[3]Post N, Yu R, Greenlee S, et al. Metabolism and Disposition of Volanesorsen, a 2'-O- (2 methoxyethyl) Antisense Oligonucleotide, Across Species. Drug Metab Dispos. 2019;47 (10) :1164-1173. |[4]Lightbourne M, et al. Volanesorsen, an Antisense Oligonucleotide to Apolipoprotein-CIII, Decreases Triglycerides and Increases Lipoprotein Lipase Activity in Partial Lipodystrophy. Journal of the Endocrine Society, 2021, 5 (Supplement_1) : A305-A305.|[5]Paik J, et al. Volanesorsen: first global approval. Drugs, 2019, 79 (12) : 1349-1354.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Launched
Isoform
ApoC3

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