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ABCG2 Polyclonal Antibody

CAT: 0498-bs-4780RSize: 100 µLDry Ice: NoHazardous: No
CAT#:0498-bs-4780RSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
An ABC transporter. Allows efflux of Hoechst dye, a property that has been used to separate bone marrow side population cells, which express BCRP/ABCG2. Appears to play a major role in the multidrug resistance phenotype of a specific MCF-7 breast cancer cell line. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.Breast Cancer Resistance Protein (BCRP) is a 70 kDa ATP-Binding Cassette membrane transport protein involved in multidrug resistance. BCRP may be over-expressed in cancer cell lines selected with doxorubicin / verapamil, topotecan or mitoxantrone.
Synonyms
ABC transporter; ABC15; ABCG 2; ABCG2; ABCG2_HUMAN; ABCP; ATP binding cassette sub family G WHITE member 2; ATP binding cassette transporter G2; ATP-binding cassette sub-family G member 2; BCRP; BCRP1; BMDP; Breast cancer resistance protein; CD338; CDw338; CDw338 antigen; EST157481; GOUT1; MGC102821; Mitoxantrone resistance associated protein; Mitoxantrone resistance-associated protein; MRX; Multi drug resistance efflux transport ATP binding cassette sub family G WHITE member 2; MXR; MXR1; Placenta specic ATP binding cassette transporter; Placenta specic MDR protein; Placenta-specic ATP-binding cassette transporter; UAQTL1.
Gene ID
9429
Cellular Locus
Extracellular
Host
Rabbit
Cross Reactivity
Human, Rat
Target
ABCG2
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human ABCG2/CD338
Applications
WB, IHC-P, IF (IHC-P)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), IHC-P (1:200-400), IF (IHC-P) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
9429
Predicted Cross Reactivity
Mouse

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