NOX2 Polyclonal Antibody, APC Conjugated

• Background:

  Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H (+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.

• Synonyms:

  CGD; NOX2; IMD34; AMCBX2; GP91-1; GP91PHOX; p91-PHOX; GP91-PHOX; Cytochrome b-245 heavy chain; CGD91-phox; Cytochrome b (558) subunit beta; Cytochrome b558 subunit beta; Heme-binding membrane glycoprotein gp91phox; NADPH oxidase 2; Neutrophil cytochrome b 91 kDa polypeptide; Superoxide-generating NADPH oxidase heavy chain subunit; p22 phagocyte B-cytochrome; CYBB

• Gene ID:

  1536

• Swiss Prot:

  P04839

• Cellular Locus:

  Cell membrane

• Host:

  Rabbit

• Cross Reactivity:

  Human, Mouse, Rat

• Immunogen:

  501-570/570

• Target:

  NOX2

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Conjugation:

  APC

• Source:

  KLH conjugated synthetic peptide derived from human NOX2/gp91phox

• Applications:

  WB, FCM, IF (IHC-P), IF (IHC-F), IF (ICC)

• Purification:

  Purified by Protein A.

• Excitation Emission:

  650nm/660nm

• Concentration:

  1µg/µl

• Dilution:

  WB (1:300-5000), FCM (1:20-100), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

• Buffer:

  Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification:

  Unmodified

• Storage Conditions:

  Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

• Gene ID URL:

  1536

• Predicted Cross Reactivity:

  Dog, Cow, Pig, Horse, Chicken, Rabbit