Complement C3 Polyclonal Antibody, PE Conjugated

• Background:

  C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity) . It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation. Acylation stimulating protein: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2 (PubMed:837664, PubMed:29953, PubMed:959512, PubMed:1432298, PubMed:15833747, PubMed:16333141, PubMed:1961575) .

• Synonyms:

  ASP; C3a; C3b; AHUS5; ARMD9; CPAMD1; HEL-S-62p; Complement C3; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; C3

• Gene ID:

  718

• Swiss Prot:

  P01024

• Cellular Locus:

  Secreted

• Host:

  Rabbit

• Cross Reactivity:

  Human

• Immunogen:

  1551-1663/1663

• Target:

  Complement C3

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Conjugation:

  PE

• Source:

  KLH conjugated synthetic peptide derived from human Complement C3 alpha chain

• Applications:

  WB, IF (IHC-P)

• Purification:

  Purified by Protein A.

• Excitation Emission:

  496,564nm/578nm

• Concentration:

  1µg/µl

• Dilution:

  WB (1:300-5000), IF (IHC-P) (1:50-200)

• Buffer:

  Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification:

  Unmodified

• Storage Conditions:

  Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

• Gene ID URL:

  718