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Pentabromophenol

CAT: 0804-HY-W105318-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W105318-01Size:1 g
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Description
Pentabromophenol (PBP) is a brominated flame retardant (BFR) widely used in various consumer products to reduce the flammability of materials used in different utility items. Pentabromophenol can accelerate the degradation of transforming growth factor-β (TGF-β) receptors by promoting clathrin-mediated endocytosis, thereby inhibiting the TGF-β signaling pathway. Additionally, Pentabromophenol can also induce apoptosis in peripheral blood mononuclear cells (PBMCs) [1][2].
CAS Number
608-71-9
Product Name Alternative
PBP
UNSPSC
12352005
Hazard Statement
H301+H311+H331, H315, H319, H335, H400
Target
Apoptosis; TGF-beta/Smad
Type
Reference compound
Related Pathways
Apoptosis; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pentabromophenol.html
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C1(=C(C(=C(C(=C1Br)Br)O)Br)Br)Br
Molecular Formula
C6HBr5O
Molecular Weight
488.59
Precautions
H301+H311+H331, H315, H319, H335, H400
References & Citations
[1]Chen CL, et al. Pentabromophenol suppresses TGF-β signaling by accelerating degradation of type II TGF-β receptors via caveolae-mediated endocytosis. Sci Rep. 2017;7:43206. Published 2017 Feb 23.|[2]Barańska A, et al. Apoptosis-Inducing Potential of Selected Bromophenolic Flame Retardants 2,4,6-Tribromophenol and Pentabromophenol in Human Peripheral Blood Mononuclear Cells. Molecules. 2022 Aug 9;27 (16) :5056.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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