SLAMF7 Polyclonal Antibody

• Background :

  SLAMF7 contains one Ig-like C2-type (immunoglobulin-like) domain. Isoform 1 mediates NK cell activation through a SAP-independent extracellular signal-regulated ERK-mediated pathway. It may play a role in lymphocyte adhesion. Isoform 3 does not mediate any activation. SAP can bind the cytoplasmic tail of isoform 1 when phosphorylated in the presence of Fyn (in vitro) . SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. The isoform 3 is expressed at much lower level than isoform 1. There are three named isoforms.

• Synonyms :

  19A; 19A24 protein; CD 319; CD2 like receptor activating cytotoxic cells; CD2 subset 1; CD319; CD319 antigen; CRACC; CS1; Membrane protein FOAP 12; Novel Ly9; Novel LY9 lymphocyte antigen 9 like protein; Protein 19A; SLAM family member 7; SLAMF 7.

• Swiss Prot :

  Q9NQ25

• Cellular Locus :

  Cell membrane

• Host :

  Rabbit

• Immunogen :

  51-160/335

• Target :

  SLAMF7

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Conjugation :

  Unconjugated

• Source :

  KLH conjugated synthetic peptide derived from human SLAMF7

• Applications :

  WB, ELISA, FCM

• Purification :

  Purified by Protein A.

• Concentration :

  1µg/µl

• Dilution :

  WB (1:300-5000), ELISA (1:500-1000), FCM (1:20-100)

• Buffer :

  0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification :

  Unmodified

• Storage Conditions :

  Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

• Predicted Cross Reactivity :

  Human, Mouse, Rat, Cow