Products for Research Use Only
RegisterLogin

Smad4

CAT: 0498-bs-23967RSize: 100 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0498-bs-23967RSize:100 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor) . Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Synonyms
Mothers against decapentaplegic homolog 4; (Small) Mothers Against Decapentaplegic; Deleted in Pancreatic Carcinoma; Deleted in pancreatic carcinoma locus 4; Deletion target in pancreatic carcinoma 4; DPC 4; DPC4; hSMAD4; JIP; MAD homolog 4; MAD mothers against decapentaplegic Drosophila homolog 4; MAD mothers against decapentaplegic homolog 4; MADH 4; MADH4; Med; Medea; Mothers against decapentaplegic homolog 4; Mothers against DPP homolog 4; OTTHUMP00000163548; Smad 4; SMAD family member 4; SMAD mothers against DPP homolog 4.
Gene ID
4089
Swiss Prot
Q13485
Cellular Locus
Cytoplasm, Nucleus
Host
Rabbit
Cross Reactivity
Human
Immunogen
1-100/552
Target
SMAD4
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human Smad4
Applications
WB
Purification
Purified by Protein A.
Concentration
1mg/ml
Dilution
WB (1:300-5000)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
4089
Predicted Cross Reactivity
Mouse, Rat, Cow, Sheep, Pig, Horse, Rabbit

Related Products

CatalogName
bs-2973RSMAD1 + SMAD5 Polyclonal Antibody
bs-8844RSMAD8/SMAD9 Polyclonal Antibody
bs-2973R-Cy7SMAD1 + SMAD5 Polyclonal Antibody, Cy7 Conjugated
bs-2973R-BiotinSMAD1 + SMAD5 Polyclonal Antibody, Biotin Conjugated
bs-8853R-01Phospho-Smad2/Smad3 (Thr8) Polyclonal Antibody
bs-8844R-FITCSMAD8/SMAD9 Polyclonal Antibody, FITC Conjugated
bs-8844R-HRPSMAD8/SMAD9 Polyclonal Antibody, HRP Conjugated
bs-8844R-Cy7SMAD8/SMAD9 Polyclonal Antibody, Cy7 Conjugated
bs-2973R-RBITCSMAD1 + SMAD5 Polyclonal Antibody, RBITC Conjugated
bs-2973R-PESMAD1 + SMAD5 Polyclonal Antibody, PE Conjugated

Alternative Products

CatalogName
pro-459SMAD4
YP-W28601-01Mouse Smad4 (Smad4) ELISA Kit
YP-W17597-01Human Smad4 (Smad4) ELISA Kit
NBP3-07262-20ugMouse Monoclonal Smad4 Antibody (SMAD4/2440)
NBP3-07264-20ugMouse Monoclonal Smad4 Antibody (SMAD4/2524)

Popular Products