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Aphidicolin

CAT: 0957-S7661Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0957-S7661Size:1 mg
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Description
Aphidicolin is a tetracyclic diterpenoid antibiotic produced by *Cephalosporium aphidicola* that specifically inhibits eukaryotic DNA polymerases α and δ, thereby blocking DNA replication and mitotic cell division. This compound demonstrates broad antiviral activity, including inhibition of herpes simplex virus replication and anti-orthopoxvirus effects. Additionally, aphidicolin enhances arabinosyl nucleoside-induced apoptosis in HL-60 human promyelocytic leukemia cells.
CAS Number
38966-21-1
Target
DNA/RNA Synthesis
Activity
Cell Cycle
Molecular Formula
C20H34O4

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