CDK1/Cyc B-IN-1
CAT:
804-HY-147646-02
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
CDK1/Cyc B-IN-1
- CAS Number: 2459916-56-2
- UNSPSC Description: CDK1/Cyc B-IN-1 (Compound 5) is a selective CDK1/Cyc B complex inhibitor with an IC50 of 97 nM. CDK1/Cyc B-IN-1 triggers apoptosis and G2/M cell cycle arrest. CDK1/Cyc B-IN-1 shows broad-spectrum cytotoxic action against cancer cell lines[1].
- Target Antigen: Apoptosis; CDK
- Type: Reference compound
- Related Pathways: Apoptosis;Cell Cycle/DNA Damage
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/cdk1-cyc-b-in-1.html
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: COC1=CC=C(C(OC)=C1)N2C(SC3=C2N=C(N=C3Cl)C)=S
- Molecular Weight: 353.85
- References & Citations: [1]Mohamed SH, et al. An investigative study of antitumor properties of a novel thiazolo[4,5-d]pyrimidine small molecule revealing superior antitumor activity with CDK1 selectivity and potent pro-apoptotic properties. Bioorg Med Chem. 2020 Sep 1;28(17):115633.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported