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Ginsenoside Rb3

CAT: 0957-S9208Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0957-S9208Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ginsenoside Rb3, extracted from the plant Panax ginseng, plays important roles in cardiovascular diseases, including myocardial ischemia-reperfusion (I/R) injury. Ginsenoside Rb3 (0.1-10 μM) is tested for inhibition of tumor necrosis factor-α (TNF) -induced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) luciferase reporter activity using a human kidney 293T cell-based assay. Ginsenoside Rb3 shows the significant activity with an IC50 of 8.2 μM. Ginsenoside Rb3 also inhibits the induction of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) messenger Ribonucleic acid (mRNA) in a dose-dependent manner after HepG2 cells have been treated with TNF-α (10 ng/mL) .
CAS Number
68406-26-8
Target
NF-κB
Activity
NF-κB
Molecular Formula
C53H90O22
Storage Conditions
3 years -20°C powder

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