c-Myc (Acetyl Lys148) rabbit pAb

c-Myc (Acetyl Lys148) rabbit pAb

• Description: Disease: A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t (8;12) (q24;q22) with BTG1. Disease: Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. function: Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes. online information: Myc entry, PTM: Phosphorylated by PRKDC. similarity: Contains 1 basic helix-loop-helix (bHLH) domain. subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B.
• Synonyms: Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39;bHLHe39;Proto-oncogene c-Myc;Transcription factor p64)
• Gene ID: 4609
• UniProt: P01106
• Cellular Locus: Nucleus, nucleoplasm. Nucleus, nucleolus.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthesized peptide derived from human c-Myc (Acetyl Lys148)
• Clonality: Polyclonal
• Validated Applications: WB, ELISA
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: WB 1:1000-2000 ELISA 1:5000-20000
• Molecular Weight: 55kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.