UAP56 Polyclonal Antibody

CAT: 0498-bs-20587RSize: 100 µLDry Ice: NoHazardous: No
CAT#:0498-bs-20587RSize:100 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and ALYREF/THOC4. Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2 and ALYREF/THOC4.
Synonyms
56 kDa U2AF65-associated protein; ATP-dependent RNA helicase p47; B (0, +) -type amino acid transporter 1; BAT1; Bat1a; DEAD box protein UAP56; Glycoprotein-associated amino acid transporter b0, +AT1; HLA-B-associated transcript 1 protein; HLA-B-associated transcript 1A; HLA-B-associated transcript-1; p47; Solute carrier family 7 member 9; Spliceosome RNA helicase BAT1; UAP56; 56 kDa U2AF65-associated protein; ATP-dependent RNA helicase p47; 0610030D10Rik; 4F2-LC6; AI428441; D17H6S81E; D17H6S81E-1; D6S81E; D6S81Eh; DDX39B; DX39B_HUMAN; Glycoprotein-associated amino acid transporter b0, +AT1; MGC127051; MGC19235; MGC38799; nuclear RNA helicase (DEAD family) ; OTTHUMP00000029229; OTTHUMP00000165889; OTTHUMP00000165890; Spliceosome RNA helicase DDX39B; U2AF65-associayed protein, 56-KD.
Gene ID
7919
Swiss Prot
Q13838
Cellular Locus
Cytoplasm, Nucleus
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Immunogen
1-100/428
Target
UAP56
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human UAP56
Applications
WB, ELISA
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
7919
Predicted Cross Reactivity
Cow, Pig

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