GRINA Polyclonal Antibody

• Background :

  Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Synaptic and extrasynaptic NMDA receptors have been shown to have opposite effects on neuronal survival, CREB function and gene regulation. As one of the four major proteins of the NMDA receptor ion channel, GRINA (Glutamate [NMDA] receptor-associated protein 1), also designated NMDA receptor glutamate-binding subunit or putative MAPK-activating protein PM02, is a 371 amino acid multi-pass transmembrane protein. Due to the chromosomal location of the gene encoding GRINA, studies have linked possible GRINA involvement with a form of idiopathic generalized epilepsy.

• Synonyms :

  Glutamate [NMDA] receptor associated protein 1; Glutamate receptor, ionotropic, N methyl D aspartate associated protein 1 (glutamate binding) ; Glutamate receptor, NMDA subtype, glutamate binding subunit; HNRGW; LFG1; MGC99687; NMDA receptor glutamate binding subunit; NMDARA1; Putative MAPK activating protein PM02; TMBIM3; Transmembrane BAX inhibitor motif containing 3; LFG1_HUMAN.

• Gene ID :

  2907

• Swiss Prot :

  Q7Z429

• Host :

  Rabbit

• Cross Reactivity :

  Mouse, Rat

• Immunogen :

  1-100/371

• Target :

  GRINA

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Conjugation :

  Unconjugated

• Source :

  KLH conjugated synthetic peptide derived from human GRINA

• Applications :

  IHC-P, IHC-F, IF (ICC), IF

• Purification :

  Purified by Protein A.

• Concentration :

  1µg/µl

• Dilution :

  IHC-P (1:200-400), IHC-F (1:100-500), IF (ICC) (1:50-200), IF ()

• Buffer :

  0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification :

  Unmodified

• Storage Conditions :

  Store at -20°C for 12 months.

• Gene ID URL :

  2907

• Predicted Cross Reactivity :

  Human, Cow, Sheep, Rabbit