RASGRP4 Polyclonal Antibody

• Background:

  The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

• Synonyms:

  RASGRP-4; GRP4_HUMAN; Guanyl nucleotide releasing protein 4; RAS guanyl releasing protein 4; RAS guanyl-releasing protein 4; RASGRP 4.

• Gene ID:

  115727

• Swiss Prot:

  Q8TDF6

• Host:

  Rabbit

• Cross Reactivity:

  Rat

• Immunogen:

  501-600/673

• Target:

  RASGRP4

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Conjugation:

  Unconjugated

• Source:

  KLH conjugated synthetic peptide derived from human RASGRP4

• Applications:

  IHC-P, IHC-F, IF (ICC), IF

• Purification:

  Purified by Protein A.

• Concentration:

  1µg/µl

• Dilution:

  IHC-P (1:200-400), IHC-F (1:100-500), IF (ICC) (1:50-200), IF ()

• Buffer:

  0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification:

  Unmodified

• Storage Conditions:

  Store at -20°C for 12 months.

• Gene ID URL:

  115727

• Predicted Cross Reactivity:

  Human, Mouse, Dog, Cow, Sheep, Horse