RegisterLogin

TRF2 Polyclonal Antibody

CAT: 0498-bs-1922RSize: 100 µLDry Ice: NoHazardous: No
CAT#:0498-bs-1922RSize:100 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length.
Synonyms
TRF2; TRBF2; Telomeric repeat-binding factor 2; TTAGGG repeat-binding factor 2; Telomeric DNA-binding protein; TERF2
Gene ID
7014
Swiss Prot
Q15554
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Human, Mouse
Immunogen
301-400/500
Target
TRF2
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human TRF2
Applications
WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
7014
Predicted Cross Reactivity
Rat, Dog, Pig, Rabbit

Related Products

CatalogName
bsm-61777R-01TRF2 Recombinant Antibody
bsm-61777R-TRTRF2 Recombinant Antibody
bsm-61777R-Cy7-01TRF2 Recombinant Antibody, Cy7 Conjugated
bsm-61777R-Biotin-01TRF2 Recombinant Antibody, Biotin Conjugated
bsm-61777R-HRP-01TRF2 Recombinant Antibody, HRP Conjugated
bsm-61777R-Cy5-TRTRF2 Recombinant Antibody, Cy5 Conjugated
bsm-61777R-FITC-TRTRF2 Recombinant Antibody, FITC Conjugated
bsm-61777R-PE-TRTRF2 Recombinant Antibody, PE Conjugated
bsm-61777R-Biotin-TRTRF2 Recombinant Antibody, Biotin Conjugated
bsm-61777R-APC-TRTRF2 Recombinant Antibody, APC Conjugated

Alternative Products

CatalogName
APG01073GPolyclonal TERF2 / TRF2 Antibody
E28PT8027TRF2 Rabbit Polyclonal Antibody
TMAB-13759-01Anti-TRF2 Polyclonal Antibody
TA382420TRF2 (TERF2) Rabbit Polyclonal Antibody
TMAB-13758-01Anti-TRF2 Polyclonal Antibody 3
C03797Cy5TRF2 Polyclonal Antibody Cy5 Conjugated
AP22995PU-NTRF2 (TERF2) Goat Polyclonal Antibody
TMAB-13757-01Anti-TRF2 Polyclonal Antibody 2
TA353494LRabbit polyclonal anti-Human TRF2 antibody
TMAC-04116-01Anti-Phospho-TRF2 (Ser323) Polyclonal Antibody

Popular Products