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IRF1-IN-2

CAT: 0804-HY-171007-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-171007-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IRF1-IN-2 (Compound I-19) is an IRF1 inhibitor. IRF1-IN-2 decreases the recruitment of IRF1 to the promoter of CASP1. IRF1-IN-2 inhibits cell death signaling pathway (i.e., cleavage of Caspase 1, GSDMD, IL-1 and PARP1; inhibits the Pho of TKB1, upregulates GPX4 and downregulates FACL4) . IRF1-IN-2 has a protective effect on ionizing radiation-induced inflammatory skin injury[1].
CAS Number
708245-32-3
UNSPSC
12352005
Target
Caspase; Glutathione Peroxidase; IFNAR; Interleukin Related; PARP; Pyroptosis
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/irf1-in-2.html
Purity
99.83
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(S(=O)(N2CCCC2)=O)C=C1)C3=CC=CC=C3OC
Molecular Formula
C18H20N2O4S
Molecular Weight
360.43
References & Citations
[1]Geng, et al. Chaperone- and PTM-mediated activation of IRF1 tames radiation-induced cell death and the inflammatory response. Cell Mol Immunol. 2024 Aug;21 (8) :856-872.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 1; GPX4; IL-1; PARP1

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