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Cinobufagin

CAT: 0957-S3224-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0957-S3224-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cinobufagin (Cinobufagine), an active ingredient of Venenum Bufonis, inhibits tumor development. Cinobufagin increases ATM and Chk2 and decreases CDC25C, CDK1, and cyclin B. Cinobufagin inhibits PI3K, AKT and Bcl-2 while increases levels of cleaved caspase-9 and caspase-3. Thus, Cinobufagin induces cell cycle arrest at the G2/M phase and apoptosis.
CAS Number
470-37-1
Synonyms
Cinobufagine
Target
ATM/ATR
Activity
PI3K/Akt/mTOR
Molecular Formula
C26H34O6
Storage Conditions
3 years -20°C powder

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