TFRC Polyclonal Antibody

• Background :

  Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity) . A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.

• Synonyms :

  Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; T9; p90; TFRC

• Gene ID :

  7037

• Swiss Prot :

  P02786

• Cellular Locus :

  Cell membrane

• Host :

  Rabbit

• Cross Reactivity :

  Human, Mouse

• Immunogen :

  21-120/760

• Target :

  TFRC

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Conjugation :

  Unconjugated

• Source :

  KLH conjugated synthetic peptide derived from human Transferrin receptor

• Applications :

  ELISA, FCM

• Purification :

  Purified by Protein A.

• Concentration :

  1µg/µl

• Dilution :

  ELISA (1:500-1000), FCM (1:20-100)

• Buffer :

  0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification :

  Unmodified

• Storage Conditions :

  Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

• Gene ID URL :

  7037

• Predicted Cross Reactivity :

  Rat