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Osavampator

CAT: 0957-E5887-02Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0957-E5887-02Size:25 mg
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Description
Osavampator (TAK-653, NBI-1065845) is a positive allosteric modulator (PAM) of AMPA receptors. It enhances glutamate-induced calcium influx in CHO cells expressing human AMPA receptors with an EC50 of 3.3 μM and potentiates AMPA receptor-mediated currents in rat primary hippocampal neurons with an EC50 of 4.4 μM.
CAS Number
1358751-06-0
Synonyms
TAK-653, NBI-1065845
Target
GluR
Activity
Neuronal Signaling
Molecular Formula
C19H23N3O3S

Chemical Information

Tak-653

TAK-653 is under investigation in clinical trial NCT03312894 (Efficacy and Safety of TAK-653 in Treatment-resistant Depression).

CAS Number1358751-06-0
PubChem CID56655833
IUPAC Name9-(4-cyclohexyloxyphenyl)-7-methyl-3,4-dihydropyrazino[2,1-c][1,2,4]thiadiazine 2,2-dioxide
Molecular FormulaC19H23N3O3S
Molecular Weight373.5
XLogP2.7
Topological Polar Surface Area79.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count26
Formal Charge0
Complexity722
SMILES
CC1=CN2CCS(=O)(=O)N=C2C(=N1)C3=CC=C(C=C3)OC4CCCCC4
InChI
InChI=1S/C19H23N3O3S/c1-14-13-22-11-12-26(23,24)21-19(22)18(20-14)15-7-9-17(10-8-15)25-16-5-3-2-4-6-16/h7-10,13,16H,2-6,11-12H2,1H3
InChIKey
PXJBHEHFVQVDDS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Tak-653
CAS: 1358751-06-0
CID: 56655833
Formula: C19H23N3O3S
MW: 373.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight373.5
XLogP32.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass373.14601278
Monoisotopic Mass373.14601278
Topological Polar Surface Area79.7 Ų
Heavy Atom Count26
Formal Charge0
Complexity722
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
C03620-01Osavampator
A24252-5Osavampator (TAK-653, NBI-1065845) 5mg
A24252-100Osavampator (TAK-653, NBI-1065845) 100mg
A24252-50Osavampator (TAK-653, NBI-1065845) 50mg
A24252-10Osavampator (TAK-653, NBI-1065845) 10mg

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