Centaurin alpha 2 Polyclonal Antibody

• Background :

  The ADP-ribosylation factor (ARF) family of small GTP-binding proteins are involved in vesicular transport regulation and in controlling cytoskeletal organization and cell adhesion. The Centaurin GTPase-activating protein family comprise a subset of ARF regulatory molecules that transduce PI 3-kinase activation into coordinated control of ARF-dependent pathways. This family includes ASAP1, ACAP1, ACAP2, AGAP1, ARAP1, ARAP2, Centaurin a1, Centaurin g3 and the recently discovered Centaurin a2. Expressed in a wide variety of tissues such as fat, heart and skeletal muscle, Centaurin a2 is thought to negatively regulate ARF-mediated actin rearrangement by binding activated PI 3-kinase. Although the exact function of Centaurin a2 is not yet known, its high sequence similarity with Centaurin a1 suggests that it may also act as an ARF6 GTPase.

• Synonyms :

  ADAP2; ADAP2_HUMAN; Arf-GAP with dual PH domain-containing protein 2; ArfGAP with dual PH domains 2; cent b; Centa 2; CENTA2; Centaurin alpha 2; Centaurin alpha 2 protein; Centaurin beta; Centaurin-alpha-2; Cnt-a2; HSA272195.

• Gene ID :

  55803

• Swiss Prot :

  Q9NPF8

• Cellular Locus :

  Cytoplasm, Cell membrane

• Host :

  Rabbit

• Cross Reactivity :

  Human, Rat

• Immunogen :

  201-300/381

• Target :

  Centaurin alpha 2

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Conjugation :

  Unconjugated

• Source :

  KLH conjugated synthetic peptide derived from human Centaurin alpha 2

• Applications :

  WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

• Purification :

  Purified by Protein A.

• Concentration :

  1µg/µl

• Dilution :

  WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

• Buffer :

  0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification :

  Unmodified

• Storage Conditions :

  Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

• Specificity :

  Possible cross-reactivity with ADAP1 (85% homology with the immunogen sequence; 43kDa)

• Gene ID URL :

  55803

• Predicted Cross Reactivity :

  Mouse, Dog, Cow, Sheep, Pig, Horse, Rabbit