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DCPIB

CAT: 0804-HY-103371-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103371-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DCPIB is a selective, reversible and potent inhibitor of volume-regulated anion channels (VRAC) . DCPIB voltage-dependently activates potassium channels TREK1 and TRAAK, and inhibits TRESK, TASK1 and TASK3 (IC50s: 0.14, 0.95, 50.72 μM, respectively) . DCPIB is also a selective blocker of swelling-induced chloride current (ICl, swell), with an IC50 of 4.1 μM. DCPIB is a useful tool for investigating structure-function studies of K2P channels[1][2].
CAS Number
82749-70-0
UNSPSC
12352005
Hazard Statement
H301, H318, H413
Target
Chloride Channel; Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dcpib.html
Purity
99.83
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)CCCOC1=CC2=C(C(C(C3CCCC3)(CCCC)C2)=O)C(Cl)=C1Cl
Molecular Formula
C22H28Cl2O4
Molecular Weight
427.36
Precautions
H301, H318, H413
References & Citations
[1]Lv J, et al. DCPIB, an Inhibitor of Volume-Regulated Anion Channels, Distinctly Modulates K2P Channels. ACS Chem Neurosci. 2019 Apr 17.|[2]Decher N, et al. DCPIB is a novel selective blocker of I (Cl, swell) and prevents swelling-induced shortening of guinea-pig atrial action potential duration. Br J Pharmacol. 2001 Dec;134 (7) :1467-79.|[3]Qingdong Han, et al. DCPIB, a potent volume-regulated anion channel antagonist, attenuates microglia-mediated inflammatory response and neuronal injury following focal cerebral ischemia. Brain Res. 2014 Jan 13;1542:176-85.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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