Braco-19 (trihydrochloride)

Braco-19 (trihydrochloride)

• CAS Number: 1177798-88-7
• UNSPSC Description: Braco-19 trihydrochloride is a potent telomerase/telomere inhibitor, preventing the capping and catalytic action of telomerase. Braco-19 acts as G-quadruplex (GQ) binding ligand, stabilizing G-quadruplexes formation at the 3V telomeric DNA overhang and produce rapid senescence or selective cell death. Braco-19 is also a HAdV virus replication inhibitor[1][2].
• Target Antigen: CMV; DNA/RNA Synthesis
• Type: Reference compound
• Related Pathways: Anti-infection;Cell Cycle/DNA Damage
• Applications: COVID-19-anti-virus
• Field of Research: Cancer; Infection
• Assay Protocol: https://www.medchemexpress.com/braco-19-trihydrochloride.html
• Solubility: H2O : 22 mg/mL (ultrasonic;warming)|DMSO : 50 mg/mL (ultrasonic;warming;heat to 80°C)
• Smiles: CN(C1=CC=C(NC2=C(C=CC(NC(CCN3CCCC3)=O)=C4)C4=NC5=CC(NC(CCN6CCCC6)=O)=CC=C52)C=C1)C.Cl.Cl.Cl
• Molecular Weight: 703.14
• References & Citations: [1]Angelika M Burger, et al. The G-quadruplex-interactive Molecule BRACO-19 Inhibits Tumor Growth, Consistent With Telomere Targeting and Interference With Telomerase Function. Cancer Res. 2005 Feb 15;65(4):1489-96.|[2]Prativa Majee, et al. Genome-wide Analysis Reveals a Regulatory Role for G-quadruplexes During Adenovirus Multiplication. Virus Res. . 2020 Jul 2;283:197960.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported