GCAP2 Polyclonal Antibody

CAT: 0498-bs-13307RSize: 100 µLDry Ice: NoHazardous: No
CAT#:0498-bs-13307RSize:100 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
The intracellular stimulation of guanylate cyclase (GC) by calcium, a key event in the recovery of the dark state of rod photoreceptors after exposure to light, is mediated by guanylate cyclase-activating protein (GCAP1) . GCAPs are calcium-binding proteins belonging to the calmodulin superfamily. GCAP1 is a calcium-binding protein that stimulates synthesis of cGMP in photoreceptors. GCAP1 is present in rod and cone photoreceptor outer segments where phototransduction occurs. In contrast to other calcium-binding proteins from the calmodulin superfamily, the calcium-free form of GCAP1 stimulates the effector enzyme. By molecular cloning of human and mouse GCAP cDNA, the known mammalian GCAPs are found to be more than 90% similar, consisting of 201 to 205 amino acids and containing three identically conserved calcium-binding sites. A related protein, GCAP2, is detectable only in the retina and results from a gene duplication event. The genes which encode GCAP1 and GCAP2 map to human chromosome 6p21.1.
Synonyms
GCAP 2; Guanylate Cyclase Activating Protein Photoreceptor 2; Guanylate Cyclase Activator 1B; Guanylin 2; Guanylyl cyclase-activating protein 2; GUC1B_HUMAN; GUCA 2; GUCA1B.
Gene ID
2979
Cellular Locus
Cell membrane
Host
Rabbit
Immunogen
21-120/200
Target
GCAP2
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human GCAP2
Applications
WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
2979
Predicted Cross Reactivity
Human, Mouse, Rat, Cow, Sheep, Horse, Rabbit

Related Products

CatalogName
bs-13306RGCAP1 Polyclonal Antibody
bs-13308RGCAP3 Polyclonal Antibody
bs-13308R-PEGCAP3 Polyclonal Antibody, PE Conjugated
bs-13308R-Cy5GCAP3 Polyclonal Antibody, Cy5 Conjugated
bs-13308R-BiotinGCAP3 Polyclonal Antibody, Biotin Conjugated
bs-13308R-APCGCAP3 Polyclonal Antibody, APC Conjugated
bs-13306R-PerCPGCAP1 Polyclonal Antibody, PerCP Conjugated
bs-13306R-FITCGCAP1 Polyclonal Antibody, FITC Conjugated
bs-13306R-Cy7GCAP1 Polyclonal Antibody, Cy7 Conjugated
bs-13306R-APCGCAP1 Polyclonal Antibody, APC Conjugated

Alternative Products

CatalogName
MBS9234701-01GCAP2 Polyclonal Antibody
NBP2-68721Rabbit Polyclonal GCAP2 Antibody
E28PN7755GCAP2 Rabbit Polyclonal Antibody
TA342731GCAP2 (GUCA1B) Rabbit Polyclonal Antibody
MBS9523420-01GCAP2 Antibody
SL13307R-01Rabbit Anti-GCAP2 antibody
E56G2119GCAP2 Rabbit Monoclonal Antibody
NB120-5422Mouse Monoclonal GCAP2 Antibody (A1)
E28M2883GCAP2 (7I14) Rabbit Monoclonal Antibody
H00002979-M01Mouse Monoclonal GCAP2 Antibody (5E7.)

Popular Products