FUBP1 Polyclonal Antibody

• Background:

  FUBP1 Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. FUBP2 Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE) . May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.

• Synonyms:

  Far upstream element-binding protein 1; FUBP1; FBP; FUSE-binding protein 1; DNA helicase V; hDH V; Far upstream element-binding protein 2; KHSRP; FUSE-binding protein 2; KH type-splicing regulatory protein; KSRP; p75; FBP2; FUBP2

• Gene ID:

  8880

• Swiss Prot:

  Q96AE4

• Cellular Locus:

  Nucleus

• Host:

  Rabbit

• Cross Reactivity:

  Mouse

• Immunogen:

  551-644/644

• Target:

  FUBP1

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Conjugation:

  Unconjugated

• Source:

  KLH conjugated synthetic peptide derived from human FUBP1

• Applications:

  WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

• Purification:

  Purified by Protein A.

• Concentration:

  1µg/µl

• Dilution:

  WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

• Buffer:

  0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification:

  Unmodified

• Storage Conditions:

  Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

• Specificity:

  This antibody detects both FUBP1 and FUBP2 (KHSRP)

• Gene ID URL:

  8880

• Predicted Cross Reactivity:

  Human, Rat, Dog, Cow, Sheep, Pig, Horse, Rabbit, Zebrafish