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Nogo B Polyclonal Antibody

CAT: 0498-bs-1315RSize: 100 µLDry Ice: NoHazardous: No
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CAT#:0498-bs-1315RSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The reticulon protein is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Reticulon 4 regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. It regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. May inhibit BACE1 activity and amyloid precursor protein processing.
Synonyms
Reticulon-4; Rtn4; Neurite outgrowth inhibitor; Nogo protein; Foocen; Neuroendocrine-specific protein; NSP; euroendocrine-specific protein C homolog; RTN-x; Reticulon-5; RTN 4A; Nogo-A; RTN-xL; RTN 4B; ASY; Nogo-B; RTN-xS; Foocen-M; RTN 4C; Nogo-C; Foocen-S; RTN4-B2; Rtn-T
Gene ID
68585
Swiss Prot
Q99P72
Cellular Locus
Cytoplasm, Cell membrane
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Immunogen
251-357/357
Target
Nogo B
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from Mouse Reticulon 4
Applications
WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Specificity
Based on the location of the target sequence this antibody will recognize all isoforms (Nogo-A, Nogo-B, and Nogo-C) .
Gene ID URL
68585
Predicted Cross Reactivity
Dog, Sheep

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