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TRRAP Polyclonal Antibody

CAT: 0498-bs-13146RSize: 100 µLDry Ice: NoHazardous: No
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CAT#:0498-bs-13146RSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The transcription factors c-Myc and E2F are involved in regulating cell cycle progression. Overexpression of c-Myc in certain cell types induces noncycling cells to enter the cell cycle via a mechanism involving E2F-1 (1) . E2F-1 is thought to regulate c-Myc expression via interactions with the retinoblastoma protein (2) . TRRAP (for transformation/transcription domain-associated protein) interacts specifically with both c-Myc and E2F-1. Expression of trans-activated mutant TRRAP inhibits the oncogenic transformation of both c-Myc and E2F-1, suggesting that TRRAP is required for these oncogenic transcription factor pathways (3) . TRRAP shares homology with the ATM/PI 3-kinase family, and it is highly conserved in evolution (4,5) .
Synonyms
350/400 kDa PCAF associated factor; FLJ10671; PAF 350/400; PAF 400; PAF350/400; PAF400; STAF 40; STAF40; TR AP; Tra 1; Tra1; Tra1 homolog; Transactivation / transformation domain associated protein; Transactivation/transformation domain associated protein; Transformation/transcription domain associated protein; TRAP; TRRAP_HUMAN.
Gene ID
8295
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Human, Rat
Immunogen
3401-3600/3859
Target
TRRAP
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human TRRAP
Applications
ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
8295
Predicted Cross Reactivity
Mouse, Dog, Sheep, Pig, Horse, Chicken, Xenopus laevis

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