Products for Research Use Only
RegisterLogin

FANCM Polyclonal Antibody

CAT: 0498-bs-13143RSize: 100 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0498-bs-13143RSize:100 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure, birth defects and chromosomal instability. At the cellular level, FA is characterized by spontaneous chromosomal breakage and a unique hypersensitivity to DNA cross-linking agents. The thirteen FA proteins that have been characterized are important for regulating chromosomal stability and genome surveillance. Eight of these proteins, namely FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL and FANCM, comprise the FA core complex, which catalyzes a key reaction in DNA repair: the monoubiquitination of FANCD2. FANCM (Fanconi anemia, complementation group M) is a member of the DEAD-box helicase family of proteins and contains a DEAH helicase domain and a nuclease domain. Localizing to chromatin fractions, FANCM is phosphorylated in a cell cycle-dependent manner and is believed to function as an anchor, recruiting the FA core complex to chromatin. Mutations in the gene encoding FANCM can lead to Fanconi anemia.
Synonyms
FAAP250; Fanconi anemia group M protein; Protein Hef ortholog
Gene ID
57697
Cellular Locus
Nucleus
Host
Rabbit
Immunogen
831-930/2048
Target
FANCM
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human FANCM
Applications
ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
57697
Predicted Cross Reactivity
Human

Related Products

CatalogName
bs-105531P-01Recombinant Human FANCM Protein, N-His
bs-4106RFANCG Polyclonal Antibody
bs-1580RFANCF Polyclonal Antibody
bs-13140RFANCC Polyclonal Antibody
bs-13138RFANCA Polyclonal Antibody
bs-13142RFANCE Polyclonal Antibody
bs-4106R-PerCPFANCG Polyclonal Antibody, PerCP Conjugated
bs-13142R-HRPFANCE Polyclonal Antibody, HRP Conjugated
bs-13142R-FITCFANCE Polyclonal Antibody, FITC Conjugated
bs-13140R-HRPFANCC Polyclonal Antibody, HRP Conjugated

Alternative Products

CatalogName
BS70824-01FANCM polyclonal antibody
GTR18096511FANCM Rabbit Polyclonal Antibody
NBP2-55444Rabbit Polyclonal FANCM Antibody
H00057697-B01PMouse Polyclonal FANCM Antibody
NBP1-49890Goat Polyclonal FANCM Antibody
70R-17238FANCM antibody

Popular Products