FANCC Polyclonal Antibody, FITC Conjugated

• Background :

  Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure, birth defects and chromsomal instability (1,2) . The FA Group C complementation group gene encodes the protein FANCC, which is located in both cytoplasmic and nuclear compartments. FANCC is expressed in a cell cycle-dependent manner, with the lowest levels at the G1/S boundary and the highest levels in the M-phase. The FANCC protein interacts with other FA complementation group proteins as well as non-FA proteins (3) . A human a spectrin II (designated aSpIIs) acts as a scaffold to enhance interactions between FANCC and FANCA to form a nuclear complex (4,5) . Another binding partner of FANCC is the BTB/POZ domain containing protein FAZF, which is a transcriptional repressor (6) . In hematopoietic cells expressing mutant FANCC, PKR is constitutively phosphorylated and has increased binding affinity for double-stranded RNA (7,8), which suggests that FANCC indirectly suppresses the activity of PKR. These cells are also apoptotic and are hypersensitive to IFNg and TNFa (8) . In addition, FANCC protein is involved in the activation of STAT1 through receptors for at least three hematopoietic growth and survival factors (8) .

• Synonyms :

  BA80I15.1; FA 3; FA3; FAC; FACC; FANCC; FANCC_HUMAN; Fanconi anemia complementation group C; Fanconi anemia complementation group C protein; Fanconi anemia group C protein; Fanconi pancytopenia type 3; FLJ14675; Protein FACC.

• Gene ID :

  2176

• Cellular Locus :

  Cytoplasm, Nucleus

• Host :

  Rabbit

• Cross Reactivity :

  Human

• Immunogen :

  61-160/558

• Target :

  FANCC

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Conjugation :

  FITC

• Source :

  KLH conjugated synthetic peptide derived from human FANCC

• Applications :

  WB, IF (IHC-P), IF (IHC-F), IF (ICC)

• Purification :

  Purified by Protein A.

• Excitation Emission :

  494nm/518nm

• Concentration :

  1µg/µl

• Dilution :

  WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

• Buffer :

  Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification :

  Unmodified

• Storage Conditions :

  Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

• Gene ID URL :

  2176

• Predicted Cross Reactivity :

  Mouse, Rat, Dog, Horse