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EYA4 Polyclonal Antibody

CAT: 0498-bs-13126RSize: 100 µLDry Ice: NoHazardous: No
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CAT#:0498-bs-13126RSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
A gene of chromosome 6q23 encodes the 640 amino acid protein, EYA4 (eyes absent) (1) . EYA is one of four members of the eyes absent family (1) . A 271 amino acid domain at the carboxyl terminal is highly conserved amongst the members of the eyes absent family (1) . EYA4 is expressed in the craniofacial mesenchyme, the dermamyotome, and the limb (1) . The conserved region in other EYA proteins interacts with SIX, DACH, and G-proteins, which regulate transcription in early embryonic development (1,2,3,4) . SIX translocates EYA1-3 to the nucleus, and G-proteins can stop this interaction (3,4) . Premature stop codon mutations in EYA4 cause postlingual, progressive autosomal dominant hearing loss in humans (2) . This shows that EYA4 is also vital to the mature organ of Corti (2) . EYA4 may cause oculo-dento-digital syndrome, based on its expression pattern and map postion (1) .
Synonyms
CMD1J; Deafness, autosomal dominant 10; DFNA 10; DFNA10; dJ78N10.1 eyes absent Drosophila homolog 4; dJ78N10.1 eyes absent; EYA 4; eya4; EYA4_HUMAN; Eyes absent 4; Eyes absent homolog 4 Drosophila; Eyes absent homolog 4; HGNC:3522; OTTHUMP00000040267.
Gene ID
2070
Cellular Locus
Cytoplasm, Nucleus
Host
Rabbit
Immunogen
301-400/639
Target
EYA4
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human EYA4
Applications
ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
2070
Predicted Cross Reactivity
Human, Mouse, Rat, Dog, Cow, Sheep, Pig, Horse

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