Phospho-HER4 (Tyr1056) Polyclonal Antibody, Cy5 Conjugated

• Background:

  This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].

• Synonyms:

  ErbB 4 phospho Y1056; p-ErbB 4 phospho Y1056; ErbB4; HER 4; HER4; Avian erythroblastic leukemia viral oncogene homolog 4; Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4; MGC138404; P180erbB4; Receptor protein tyrosine kinase erbB 4 precursor; Receptor tyrosine protein kinase erbB 4; Tyrosine kinase type cell surface receptor HER4; v erb a avian erythroblastic leukemia viral oncogene homolog like 4; v erb a erythroblastic leukemia viral oncogene homolog 4; Verba avian erythroblastic leukemia viral oncogene homolog like 4; Verba erythroblastic leukemia viral oncogene homolog 4; VERBB2.

• Gene ID:

  2066

• Swiss Prot:

  Q15303

• Modification Site:

  Tyr1056

• Cellular Locus:

  Cytoplasm, Nucleus, Cell membrane

• Host:

  Rabbit

• Cross Reactivity:

  Human, Rat

• Target:

  Phospho-HER4 (Tyr1056)

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Conjugation:

  Cy5

• Source:

  KLH conjugated synthetic phosphopeptide derived from human HER4 around the phosphorylation site of Tyr1056 [PA (p-Y) TP]

• Applications:

  IF (IHC-P), IF (IHC-F), IF (ICC)

• Purification:

  Purified by Protein A.

• Excitation Emission:

  625,650nm/670nm

• Concentration:

  1µg/µl

• Dilution:

  IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

• Buffer:

  Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification:

  Phosphorylation

• Storage Conditions:

  Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

• Gene ID URL:

  2066

• Predicted Cross Reactivity:

  Mouse, Cow, Sheep, Pig, Horse, Rabbit, GuineaPig