DMAP1 Polyclonal Antibody

• Background :

  Methylation of DNA contributes to the regulation of gene transcription in eukaryotic systems. DNA methylation is predominantly found on cytosine residues that are present in dinucleotide motifs consisting of a 5' cytosine followed by a guanosine (CpG), and it requires the enzymatic activity of DNA methyltransferases (DNMTs), which results in transcriptional repression of the methylated gene. DNA methyltransferase 1-associating protein (Dmap1) binds to methyl-CpG rich domains and mediate the transcriptional inhibition associated with DNA methylation. Dmap1 interacts with Daxx to enhanced Daxx-mediated repression of glucocorticoid receptor transcriptional activity. Daxx also protects Dmap1 from protein degradation in vivo.

• Synonyms :

  DKFZp686L09142; DMAP 1; DNA methyltransferase 1-associated protein 1; DNMAP 1; DNMAP1; DNMT1-associated protein 1; DNMT1-associated protein 1; DNMTAP 1; DNMTAP1; EAF 2; EAF2; FLJ11543; KIAA1425; MAT 1-mediated transcriptional repressor; MGC55593; SWC 4; SWC4; zgc:55593.

• Gene ID :

  55929

• Cellular Locus :

  Cytoplasm, Nucleus

• Host :

  Rabbit

• Immunogen :

  31-130/467

• Target :

  DMAP1

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Conjugation :

  Unconjugated

• Source :

  KLH conjugated synthetic peptide derived from human DMAP1

• Applications :

  ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

• Purification :

  Purified by Protein A.

• Concentration :

  1µg/µl

• Dilution :

  ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

• Buffer :

  0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification :

  Unmodified

• Storage Conditions :

  Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

• Gene ID URL :

  55929

• Predicted Cross Reactivity :

  Human, Mouse, Rat, Dog, Cow, Sheep, Chicken, Rabbit, Xenopus laevis