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ARN22089

CAT: 0804-HY-149464-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-149464-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ARN22089 is a oral active novel class of trisubstituted pyrimidine, blocks the interaction of CDC42 GTPases with specific downstream effectors. ARN22089 blocks tumor growth in BRAF mutant mouse melanoma model[1].
CAS Number
2248691-29-2
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/arn22089.html
Purity
98.73
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CN(C)C1=CC(NC2=CC(C3=CC=CC=C3)=NC(C4CCNCC4)=N2)=CC=C1
Molecular Formula
C23H27N5
Molecular Weight
373.49
References & Citations
[1]Brindani N, et al. Design, Synthesis, In Vitro and In Vivo Characterization of CDC42 GTPase Interaction Inhibitors for the Treatment of Cancer. J Med Chem. 2023;66 (8) :5981-6001.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
T85727-01ARN22089

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