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SRT-1460

CAT: 0957-S6880-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0957-S6880-01Size:5 mg
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Description
SRT-1460 is a potent and selective activator of Sirtuin 1 (SIRT1) with EC1.5 of 2.9 μM. SRT-1460 reduces cell viability and growth of pancreatic cancer cells and induces apoptosis.
CAS Number
925432-73-1
Target
Sirtuin
Activity
DNA Damage/DNA Repair
Molecular Formula
C26H29N5O4S
Storage Conditions
3 years -20°C powder

Chemical Information

Srt-1460

small molecule activator of SIRT1 as therapeutics for the treatment of type 2 diabetes; structure in first source

CAS Number925432-73-1
PubChem CID24180124
IUPAC Name3,4,5-trimethoxy-N-[2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]benzamide
Molecular FormulaC26H29N5O4S
Molecular Weight507.6
XLogP3.5
Topological Polar Surface Area118
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count8
Heavy Atom Count36
Formal Charge0
Complexity714
SMILES
COC1=CC(=CC(=C1OC)OC)C(=O)NC2=CC=CC=C2C3=CN4C(=CSC4=N3)CN5CCNCC5
InChI
InChI=1S/C26H29N5O4S/c1-33-22-12-17(13-23(34-2)24(22)35-3)25(32)28-20-7-5-4-6-19(20)21-15-31-18(16-36-26(31)29-21)14-30-10-8-27-9-11-30/h4-7,12-13,15-16,27H,8-11,14H2,1-3H3,(H,28,32)
InChIKey
SBEWVVLMFLTQFE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Srt-1460
CAS: 925432-73-1
CID: 24180124
Formula: C26H29N5O4S
MW: 507.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight507.6
XLogP33.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count8
Exact Mass507.19402560
Monoisotopic Mass507.19402560
Topological Polar Surface Area118 Ų
Heavy Atom Count36
Formal Charge0
Complexity714
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
HY-124037-01SRT 1460
C12285-01SRT-1460
A19026-50SRT 1460 50mg
A19026-5SRT 1460 5mg
A19026-2SRT 1460 2mg
A19026-10SRT 1460 10mg
466481-01SRT 1460-d9
A19026-100SRT 1460 100mg
A19026-25SRT 1460 25mg
TRC-S684450-1MGSRT 1460 TFA Salt

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