NE 52-QQ57

CAT: 0957-S6850-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0957-S6850-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

NE 52-QQ57 is a selective, and orally available antagonist of G-protein coupled receptor 4 (GPR4) with IC50 of 0.07 μM. NE 52-QQ57 effectively blocks GPR4-mediated cAMP accumulation with IC50 of 26.8 nM in HEK293 cells. The antagonism of GPR4 with NE 52-QQ57 significantly inhibits the AGE-induced increased expression of several key inflammatory cytokines and signaling molecules, including tumor necrosis factor-α (TNF-α), interleukin (IL) -1β, IL-6, inducible nitric oxide synthase (iNOS), nitric oxide (NO), cyclooxygenase 2 (COX2), and prostaglandin E2 (PGE2) .

CAS Number

1401728-56-0

Target

GPR

Activity

GPCR & G Protein

Molecular Formula

C24H28N6O

Storage Conditions

3 years -20°C powder

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NE 52-QQ57

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