Radiprodil (RGH-896)

CAT: 0957-S6644Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0957-S6644Size:5 mg

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Description

Radiprodil (RGH-896) is a NR2B-selective NMDA receptor antagonist, initially developed for the treatment of neuropathic pain.

CAS Number

496054-87-6

Target

NMDAR

Activity

Neuronal Signaling

Molecular Formula

C21H20FN3O4

Storage Conditions

3 years -20°C powder

Chemical Information

Radiprodil

Radiprodil has been used in trials studying the treatment of Infantile Spasms (IS) and Diabetic Peripheral Neuropathic Pain.

CAS Number	496054-87-6
PubChem CID	10200813
IUPAC Name	2-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]-2-oxo-N-(2-oxo-3H-1,3-benzoxazol-6-yl)acetamide
Molecular Formula	C21H20FN3O4
Molecular Weight	397.4
XLogP	3
Topological Polar Surface Area	87.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Heavy Atom Count	29
Formal Charge	0
Complexity	629

SMILES

C1CN(CCC1CC2=CC=C(C=C2)F)C(=O)C(=O)NC3=CC4=C(C=C3)NC(=O)O4

InChI

InChI=1S/C21H20FN3O4/c22-15-3-1-13(2-4-15)11-14-7-9-25(10-8-14)20(27)19(26)23-16-5-6-17-18(12-16)29-21(28)24-17/h1-6,12,14H,7-11H2,(H,23,26)(H,24,28)

InChIKey

GKGRZLGAQZPEHO-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 496054-87-6

CID: 10200813

Formula: C21H20FN3O4

MW: 397.4

Interactive 3D Structure

Loading 3D structure...

Computed Properties

Property	Value
Molecular Weight	397.4
XLogP3	3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Exact Mass	397.14378429
Monoisotopic Mass	397.14378429
Topological Polar Surface Area	87.7 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	629
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Catalog	Name
E6729-01	RGH-857